DNA reverse sequence in ageing mice, promising result is ready to test in human as research subjects.
- Critical step found in DNA repair, cellular aging
Scientists have found a way in DNA repair process, extending the lifespan of mice by 20 per cent and raising the prospect of an anti-ageing treatment for humans. The potential human as research subjects, people with an aggressive form of brain tumour, called Glioblastoma multiforme, in which cells happen to feature a similar marker to those in senescent cells, making the peptide a possible treatment for this form of cancer.
The latest study focused on NMN’s ability in DNA reverse sequence repair, which gets damaged every time we go out into the sun or are exposed to radiation. The ability of our cells to repair the damage decreases as we age. The scientists found that giving mice a dose of NMN in their drinking water improved the ability of their cells to repair DNA damaged by radiation or old age.
Purging retired cells from the body has been shown to undo the ravages of old age in a study that raises the prospect of new life-extending treatments .
They’ve shown that by giving a particular compound to older mice, they can activate the DNA repair process and not only protect against future damage, but repair the existing effects of ageing. And they’re ready to start testing in humans within six months.
Scientists to ‘reset’ blood proteins in attempt to slow ageing process
The team are now assessing whether the mice also live longer and are planning a series of safety test in humans. The ultimate goal of testing whether getting rid of so-called senescent cells could help reverse a range of age-related disorders. Lead author of the research, David Sinclair of the University of New South Wales and Harvard Medical School, said it was the closest scientists had come to developing a safe and effective anti-ageing drug. Its potential dates as early as 2020.
The DNA repair discovery adds to a wave of new findings hinting at the possibility of a future in which doctors can treat ageing itself, rather than trying to combat the host of diseases that come along with it.
DNA repair on human experimentation
Researchers have found a way to protect a mouse’s DNA from the damage that comes with aging, and they’re ready to test it in people.
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. It is essential for cell vitality, cell survival, and cancer prevention, yet cells’ ability to patch up damaged DNA declines with age for reasons not fully understood.
Human subject research is systematic, scientific investigation that can be either interventional or observational and involves human beings as research subjects. Human subject research can be either clinical research or non-medical research.
When mice were treated with a substance designed to sweep away cells that have entered a dormant state due to DNA damage their fur regrew, kidney function improved and they were able to run twice as far as untreated elderly animals. DNA repair / DNA reverse sequence/ Image Credits: A protein that’s more abundant in young mice appears to reverse the aging process in older animals (PHOTO)